Collection of journal articles

Health Benefits

Crocus Sativus is a flower commonly known as Saffron. The following science-based research shows how saffron may improve both physiological and psychological conditions of our body.


How To Take

For general wellbeing, it is recommended to take 20mg of Saffron in the form of supplement, spice in meals, or mixed with tea/coffee. This could be done through taking water extraction of the red part of the plant (thread) or just the dehydrated stigma for the period of 12 weeks.

For using the product as a health supplement, it is suggested to take 10mg of saffron, twice a day. The standard dosage of the product is 20mg used for 10 weeks.

When you noticed progress in general well-being, please do not stop taking the supplement. Because any progress will quickly regress. This is why it is recommended to continue with the daily dosage of the spice.


Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Please read our terms and conditions here.


Based on the following scientific research, consuming 30mg saffron daily appear to be effective in reducing depressive symptoms in people with the major depressive disorder, and the potency has been noted to be comparable to reference drugs such as fluoxetine(Prozac) and imipramine. A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms, revealing that saffron supplementation significantly reduced depression symptoms compared to the placebo control. Click here for the source.

In another systematic review, six studies were identified. In the placebo comparison trials, saffron had large treatment effects and, when compared with antidepressant medications, had similar antidepressant efficacy. Saffron's antidepressant effects potentially are due to its serotonergic, antioxidant, anti-inflammatory, neuroendocrine and neuroprotective properties. Research conducted so far provides initial support for the use of saffron for the treatment of mild-to-moderate depression. Click here for the source.

Saffron extracts are natural antidepressants as effective as Prozac. Extracts made from the popular Middle Eastern spice saffron have also recently been shown to be effective natural antidepressants in several small clinical trials. Click here for the source.

Saffron appears to have antidepressant properties secondary to the crocin content, as safranal appears to be mostly inactive. Click here for the source.

Also one more study it is noted saffron elevated mood in healthy people. Click here for the source.

Anxiety and stress

Researchers at the University of Melbourne pointed out the benefits of saffron for depression, anxiety and insomnia. Click here for the source.

Based on another research, the aroma of saffron resulted in minor reductions in anxiety, and relaxing properties via aromatherapy have been suggested. Click here for the source.

Aphrodisiac - Increase libido

Saffron may improve sexual function in men and women with major depression who are experiencing fluoxetine-induced sexual dysfunction. Click here for the source.

It is also noted saffron improves parameters of the sexual function in both men and women experiencing sexual dysfunction from Selective Serotonin Reuptake Inhibitors (SSRIs) therapy. The study showed a positive effect on sexual function with increased number and duration of erectile events seen in patients with Erectile Dysfunction (or impotence) even only after taking it for ten days. Click here for the source.

Premenstrual syndrome (PMS)

The spice could control and reduce bleeding during the menstrual cycle of women. A study shows saffron was found to be effective in relieving symptoms of PMS.  Researchers assessed how saffron would effect on PMS symptoms over two menstrual cycles. At the end of the second cycle, 76% of women reported total symptoms (but only 8% reported in placebo). There was also a reduction in depression symptoms by more than half in 60% of women taking saffron, versus only 4% of women taking placebo could achieve it. Click here for the source.


Research shows that saffron positively effective on sperm morphology and motility in infertile men, while it does not increase sperm count. Click here for the source.

AMD (Age-related Macular Degeneration)

Saffron may hold the key to preventing the loss of sight in the elderly. One of the world's first trials by researchers at the University of Sydney and in Italy has found. According to the Professor Silvia Bisti, a visiting scholar based at The VisionCentre at the University of Sydney: "Measurements using objective eyesight tests showed patient's vision improved after taking the saffron pill. When they were tested with traditional eye charts, a number of patients could read one or two lines smaller than before, while others reported they could read newspapers and books again." Click here for the source.

The crocins, a type of carotenoid found in saffron, have protective effects in retinal tissue similar to other carotenoids, and their potency in rats seems comparable to other dietary carotenoids. Click here for the source#1, source#2, source#3 and source#4.

Studies on age-related macular degeneration(AMD) have noted the benefits of saffron supplementation to visual acuity at slightly less than the standard oral dose. Click here for the source#1 and here for the source#2.

Alzheimer's disease

According to the study of several scientists, at least in the short-term, saffron is both safe and effective in mild to moderate Alzheimer’s disease. The study has been published in the Journal of Clinical Pharmacy and Therapeutics. Click here for the source.

Also Based on the literature, beneficial effects of the plant and its components on neurodegenerative disorders such as Alzheimer and Parkinson's disease are mainly due to their interactions with cholinergic, dopaminergic and glutamatergic systems. Click here for the source.

Crocins in saffron have been shown to reduce the formation of β-amyloid protein aggregates in vitro. The findings suggest the possible use of saffron stigma constituents for inhibition of aggregation and deposition of Abeta in the human brain. Click here for the source.

Weight management (Appetite Suppressant)

There has been a study on overweight women and a decrease in snacking frequency as well as subjective hunger associated with moderate weight loss is noted. Click here for the source.

Antioxidant-rich saffron compounds may modulate obesity and associated metabolic disorders. They can be potentially useful in the prevention, control, and/or management of overweight and obesity of individuals. Current knowledge about properties of saffron suggests that saffron supplementation will be at least responsible for lowering the risk of over snacking-diet associated with obesity or promoting weight loss in overweight individuals. Click here for the source.

Hormones - Corticosteroids

The aromatherapy of saffron caused a mild reduction in cortisol in otherwise healthy women.

Hormones - Estrogen

Saffron aromatherapy has resulted in a dramatic increase in estrogen in otherwise healthy women. Click here for the source.

Improving memory and learning skills

Saffron improves memory and learning skills, and increases blood flow in retina and choroid. Click here for the source.

Cancer prevention

According to National Centre for Biotechnology Information of United states of America, saffron trumps one-dimensional dangerous cancer drugs while protecting DNA. Saffron is safe compared to most conventional cancer drugs. Liver, lung, and stomach cancer are known as the deadliest forms of cancer. Tumors and tissue damage in these organs as a result of cancer have been shown to decrease and cease when saffron treatment is introduced. Click here for the source.

Studies on prostate cancer of human demonstrated a prostate cancer cell line to be very sensitive to safranal-mediated growth inhibition and apoptotic cell death. It appears to have potential as a therapeutic agent. Click here for the source.

Other studies suggest that saffron provides an anti-cancer protective effect through promoting cell death (apoptosis), inhibiting proliferation of cancerous cells, and blocking inflammation. Click here for the source.

Saffron possesses free radical-scavenging properties and antitumor activities. Significant cancer chemopreventive effects have been shown in both in-vitro and in vivo models. Based on current data, saffron and its ingredients could be considered as a promising candidate for clinical anticancer trials. Click here for the source.


The significant fall in Lipoprotein oxidation susceptibility (LOS) indicates the potential of saffron as an antioxidant. Click here for the source.

Lungs - Asthma

It has been traditionally prescribed to improve respiratory function, asthmatic problems, and as a lung tonic. In this context, a relaxant effect on tracheal smooth muscle has been described for this plant. Click here for the source.

There have been promising animal studies involving the saffron in attenuating asthma signs. But, these results have not yet been confirmed in humans. Click here for the source.

Muscle soreness

Because of the anti-mmatory properties of saffron, it has been studied in humans for the prevention of delayed-onset muscle soreness (DOMS). The study suggests taking 300 mg saffron may reduce DOMS from eccentric exercise in untrained individuals. Click here for the source.


Saffron appears to associate with DNA, and when bound to DNA, it is speculated to act in an antioxidative manner. Click here for the source#1 and here for source#2.

Skin health

Saffron-containing cream has been applied topically and the study suggests its potency is comparable or more than the homosolate( an organic compound commonly used in sunscreen). Click here for the source.

It takes 170,000 to 220,000 Crocus Sativus flowers and 400 hours of labour to produce 1kg of dried stigma saffron